Tobias Buchborn | Systems Neuroscientist
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Research

Psychedelic drugs make consciousness an experimental variable.

They provide a unique opportunity to study how defined molecular perturbations propagate across biological scales to reorganize brain dynamics and physiology, ultimately informing our understanding of multi-level homeostasis and mental health.

To trace how these perturbations unfold across neural and whole-body organisation, I draw on experimental approaches ranging from receptor pharmacology and behavioural modelling to in vivo optophysiology, including multi-site fibre photometry, voltage imaging, pulse oximetry, and thermography, as well as custom pipelines for multimodal signal integration.

Below, five experimental research directions are outlined.


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LSD restores avoidance learning in a rat model of depression
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Differential tolerance to LSD and DMT occurs via 5-HT2A regulation
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Cortical pyramidal cells set the motoric platform for psychedelic behaviour
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LSD disrupts thalamocortical glutamate release (ongoing)
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Psilocybin counteracts alcohol-seeking behaviour (ongoing)
© 2026 Tobias Buchborn
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