Research interests
- Central serotonin system and its contribution to mammal consciousness, mood, and cognition
- Serotonergic hallucinogens and correlates of hallucinogenic activity (e.g., haemo-and pyramidal-cellular 5-HT2Aergics)
- Serotonergic thermoregulation (e.g., 5-HT2A in hyperthermia)
- Neuropsychopharmacology of substances of abuse (and mechanisms of addiction)
Current project
The corticodynamics of serotonergic hallucinogens (supported by MSCA and The Beckley Foundation)
- The project addresses the 5-HT2Aergics of (brain-imminent) neck-arterial blood-flow as a function of thermoregulation (for further information: growkudos.com)
- The project addresses the haemo- and pyramidal-cellular corticodynamics of a certain behaviour, which mice show in response to all psychedelics; it asks how blood-flow and pyramidal-cellular signals come together in the (movement-governing) motor cortex at the very moment in which the psychedelic elicits the given behaviour. What is the cortical signature of "psychedelic behaviour"? (for further information: MSCA blog)
Former projects
- Regulation of serotonin (5-HT) 2A receptors and its relevance for tolerance to serotonergic hallucinogens (incl., LSD, DMT, and DOB) (for further information: youtube.com 1 and youtube.com 2)
- Evaluation of the antidepressant-like properties of LSD in an animal model of depression (i.e., olfactory bulbectomy) (for further information: psypost.org and youtube.com 2)
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Publications
Buchborn T, Lyons T, Song C, Feilding A, Knopfel T (2020). The 5-HT2AR agonist 25CN-NBOH increases murine heart rate and neck-arterial blood flow in a temperature-dependent manner. J. Psychopharmacol., 34, 7, 786–794. doi: 10.1177/0269881120903465 (green open access).
Buchborn T, Lyons T, Knopfel T (2018). Tolerance and Tachyphylaxis to Head Twitches Induced by the 5-HT2A Agonist 25CN-NBOH in Mice. Front. pharmacol., 9, 17. doi: 10.3389/fphar.2018.00017 (open access).
Buchborn T, Grecksch G, Dieterich DC, Höllt V (2016). Tolerance to lysergic acid diethylamide (LSD): Overview, correlates, and clinical implications. In: Preedy VR (ed.), Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects, 846-858. Academic Press. doi:10.1016/B978-0-12-800212-4.00079-0 (green open access).
Buchborn T, Schröder H, Koch T, Kahl E, Dieterich DC, Grecksch G, Höllt V (2016). Differential tolerance to lysergic acid diethylamide (LSD) and dimethyltryptamine (DMT) – A matter of serotonin (5-HT) 2A receptor downregulation? Naunyn-Schmiedeberg's Arch. Pharmacol., 389, Suppl. 1, S63.
Buchborn T, Schröder H, Dieterich DC, Grecksch G, Höllt V (2015). Tolerance to LSD and DOB induced Shaking behaviour: Differential adaptations of frontocortical 5-HT2A and glutamate receptor binding sites. Behav. Brain Res., 281, 62–68. doi:10.1016/j.bbr.2014.12.014 (green open access).
Buchborn T, Schröder H, Höllt V, Grecksch G (2014). Repeated lysergic acid diethylamide in an animal model of depression: Normalisation of learning behaviour and hippocampal serotonin 5-HT2 signalling. J. Psychopharmacol., 28, 6, 545-552. doi: 10.1177/0269881114531666 (green open access).
Buchborn T, Kahl E, Höllt V, Koch T (2012). Agonist-selective internalization of the human 5-HT2A receptor. Naunyn-Schmiedeberg´s Arch. Pharmacol., 385, Suppl. 1, S17. doi: 10.1007/s00210-012-0736-0 (green open access).
Buchborn T, Schröder H, Dieterich DC, Koch T, Börner C, Becker A, Grecksch G, Höllt V (in preparation). Tolerance to serotonergic hallucinogens - Differential regulation of 5-HT2A receptors by LSD and DMT.
Buchborn T, Lyons T, Knopfel T (2018). Tolerance and Tachyphylaxis to Head Twitches Induced by the 5-HT2A Agonist 25CN-NBOH in Mice. Front. pharmacol., 9, 17. doi: 10.3389/fphar.2018.00017 (open access).
Buchborn T, Grecksch G, Dieterich DC, Höllt V (2016). Tolerance to lysergic acid diethylamide (LSD): Overview, correlates, and clinical implications. In: Preedy VR (ed.), Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects, 846-858. Academic Press. doi:10.1016/B978-0-12-800212-4.00079-0 (green open access).
Buchborn T, Schröder H, Koch T, Kahl E, Dieterich DC, Grecksch G, Höllt V (2016). Differential tolerance to lysergic acid diethylamide (LSD) and dimethyltryptamine (DMT) – A matter of serotonin (5-HT) 2A receptor downregulation? Naunyn-Schmiedeberg's Arch. Pharmacol., 389, Suppl. 1, S63.
Buchborn T, Schröder H, Dieterich DC, Grecksch G, Höllt V (2015). Tolerance to LSD and DOB induced Shaking behaviour: Differential adaptations of frontocortical 5-HT2A and glutamate receptor binding sites. Behav. Brain Res., 281, 62–68. doi:10.1016/j.bbr.2014.12.014 (green open access).
Buchborn T, Schröder H, Höllt V, Grecksch G (2014). Repeated lysergic acid diethylamide in an animal model of depression: Normalisation of learning behaviour and hippocampal serotonin 5-HT2 signalling. J. Psychopharmacol., 28, 6, 545-552. doi: 10.1177/0269881114531666 (green open access).
Buchborn T, Kahl E, Höllt V, Koch T (2012). Agonist-selective internalization of the human 5-HT2A receptor. Naunyn-Schmiedeberg´s Arch. Pharmacol., 385, Suppl. 1, S17. doi: 10.1007/s00210-012-0736-0 (green open access).
Buchborn T, Schröder H, Dieterich DC, Koch T, Börner C, Becker A, Grecksch G, Höllt V (in preparation). Tolerance to serotonergic hallucinogens - Differential regulation of 5-HT2A receptors by LSD and DMT.